A large contract lab was providing services to Certified Home Inspection Companies after homes were deemed to be unsafe due to drug residues on surfaces and in HVAC ductwork. The lab wanted a screening assay to cover multiple illicit compounds that might persist even after thorough cleaning. EMSL developed a surface wipe assay that could monitor for the presence of these abused substances at the lowest levels requested of 0.1ug/wipe using Ion Trap LC/MS/MS while providing rapid turnaround in 24 hours.